to study DNA alterations. In Situ Detection of DNA Damage is the first publication solely dedicated to the in situ format. The term “in situ” incorporates analysis of both tissue sections and individual cells. The volume brings together all major in situ techniques developed to study DNA damage and apoptosis. It also expands the utility of the presented methods by showing how approaches originally designed to label apoptotic cells can be used for DNA damage analysis (and vice versa). It includes many new cutting-edge protocols that have become possible as a result of the significant progress occurring in the field during the last five years.